Cutaneous T-cell lymphoma with massive co-infiltration of polyclonal B cells.
case_report · Level V
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- Record sourced from PubMed, PMID 7510123.
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Abstract
A 76-year-old man presented with a 3-month history of a cutaneous nodule on the right thigh. The tumour was composed of CD3+, large atypical cells, and CD20+, small normal-appearing cells. Flow cytometry showed that CD20+ cells outnumbered CD3+ cells. By Southern blot hybridization analyses, the malignant cells were shown to be of T-cell origin, because of the presence of rearranged bands for the beta chain of the T-cell receptor, but not for the immunoglobulin heavy chain. This case represents a T-cell lymphoma intermingled with a large number of non-neoplastic B cells.
Medical subject headings
- B-Lymphocytes
- Leg
- Lymphoma, T-Cell
- Skin Neoplasms