Permselectivity in thin membrane nephropathy.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 7514188.
- Also identified by PMC identifier 294294.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The glomerular permselectivity to polydisperse neutral dextrans was compared in 6 patients with thin membrane nephropathy (TMN) and 10 healthy controls. Despite having normal renal hemodynamics and minimal proteinuria, the patients with TMN had significantly increased fractional clearance of neutral molecules with Stokes radius > 42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria.
Medical subject headings
- Dextrans
- Glomerulonephritis, Membranous
- Hemodynamics
- Kidney Glomerulus