Hyperfibrinolysis during intracranial surgery: effect of high dose aprotinin.
case_report · Level V
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- Record sourced from PubMed, PMID 7529819.
- Also identified by PMC identifier 1073281.
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Abstract
A patient undergoing intracranial surgery developed disseminated intravascular coagulation with life threatening peroperative bleeding. Thromboelastography established the diagnosis of hyperfibrinolysis, usually a fatal complication of a neurosurgical operation. With the administration of a high dose regimen of aprotinin (Trasylol) the haemorrhage was controlled and the hyperfibrinolytic state reversed. Evaluation of blood samples from the jugular bulb suggested that there was a pronounced local release of tissue plasminogen activator into the circulation.
Medical subject headings
- Aprotinin
- Brain
- Brain Neoplasms
- Dose-Response Relationship, Drug
- Fibrinolysis
- Glioblastoma
- Hemorrhage