Methotrexate for the treatment of severe mucocutaneous lupus erythematosus.
case_report · Level V
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Abstract
We report three women with severe, chronic mucocutaneous lupus erythematosus who showed a significant improvement during oral methotrexate therapy; the improvement was sustained after the drug was discontinued. Their disease had previously been refractory to a wide range of conventional systemic immunosuppressive therapies. Other treatments were progressively withdrawn, and control was maintained, for a variable length of time, with methotrexate alone, or with a small dose of prednisolone.
Medical subject headings
- Immunosuppressive Agents
- Lupus Erythematosus, Discoid
- Methotrexate