An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments.
basic_science · Level V
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Abstract
Golgi cisternae regrew in a cell-free system from mitotic Golgi fragments incubated with buffer alone. Pretreatment with NEM or salt washing inhibited regrowth, but this could be restored either by p97, an NSF-like ATPase, or by NSF together with SNAPs and p115, a vesicle docking protein. The morphology of cisternae regrown with p97 and NSF-SNAPs-p115 differed, suggesting that they play distinct roles in rebuilding Golgi cisternae after mitosis.
Medical subject headings
- Adenosine Triphosphatases
- Carrier Proteins
- Golgi Apparatus
- Intracellular Membranes
- Mitosis
- Vesicular Transport Proteins