Severe intracranial hemorrhage in a newborn infant with transplacental transfer of an acquired factor VII:C inhibitor.
case_report · Level V
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Abstract
We describe a woman in whom inhibitors to factor VIII:C developed in her first pregnancy. The neonate had a factor VIII:C level of 1% and an inhibitor titer of 5.2 Bethesda units. After an uneventful vaginal delivery, the boy had an intracranial hemorrhage at 5 days of age. To our knowledge, this is the first report of a bleeding complication in a newborn infant with transplacental transfer of an acquired factor VIII:C inhibitor.
Medical subject headings
- Cerebral Hemorrhage
- Factor VIII
- Hemophilia A
- Infant, Newborn
- Maternal-Fetal Exchange
- Occipital Lobe