Nucleolar organizer regions: a new prognostic factor for upper tract urothelial cancer.
prospective_cohort · Level II
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Abstract
The prognostic significance of argyrophilic staining in the nucleolar organizer regions was studied in 63 patients with primary urothelial tumors of the renal pelvis and ureter. Silver staining of paraffin embedded sections was performed using a 1-step technique. The prognosis for patients with a mean number of argyrophilic nucleolar organizer region proteins per nucleus (argyrophilic nucleolar organizer region score) of 8 or greater was significantly worse than that for patients with a score of less than 8 (P <0.001). Argyrophilic nucleolar organizer region score is a new prognostic factor in primary urothelial tumors of the renal pelvis and ureter, and it is particularly useful for patients with invasive tumors.
Medical subject headings
- Kidney Neoplasms
- Kidney Pelvis
- Ureteral Neoplasms