Merkel cells do not require trophic maintenance from the nerves in adult human skin.
case_report · Level V
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Abstract
A 34-year-old Japanese man with hereditary sensory neuropathy was examined to evaluate the distribution, density and inter-relationship between Merkel cells and peripheral nerves in the skin. An epidermal sheet of affected plantar skin showed numerous CAM 5.2-reactive Merkel cells, whereas PGP 9.5-reactive peripheral nerves were completely absent in the epidermis and dermis. These findings strongly suggest that Merkel cells do not require trophic maintenance from nerves in adult human skin.
Medical subject headings
- Hereditary Sensory and Autonomic Neuropathies
- Merkel Cells
- Skin