Successful treatment of generalized lichen planus with recombinant interferon alfa-2b.
case_report · Level V
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Abstract
Three patients with generalized lichen planus were treated with interferon alfa-2b. The therapy was tolerated well by all patients with only minor side effects. A response was observed within 2 to 3 weeks. Itching and erythema decreased first, followed by gradual flattening and disappearance of papules and plaques after 8 to 10 weeks of treatment. After 12 weeks, therapy was discontinued after stepwise dosage reduction. In two patients, minor lesions recurred during dosage reduction. Both flares were controlled by readministration of interferon.
Medical subject headings
- Antineoplastic Agents
- Antiviral Agents
- Interferon-alpha
- Lichen Planus