Identification of a nonneuronal isoform of synaptotagmin.
other · Level V
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- Record sourced from PubMed, PMID 7597049.
- Also identified by PMC identifier 41608.
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Abstract
Synaptotagmins, which have been found exclusively in neuroendocrine or exocrine tissues, have been implicated in the regulation of secretory vesicle fusion with the plasma membrane. The present paper describes a synaptotagmin isoform (synaptotagmin-5) which exhibits 49% amino acid identity to synaptotagmin-1 and -2. Synaptotagmin-5 mRNA is expressed in rat kidney, adipose tissue, lung, and heart, as well as at higher levels in brain and PC12 cells. Antiserum specific for the synaptotagmin-5 isoform recognizes a protein of about 50 kDa which is about 6-fold more abundant in brain synaptic vesicles than in whole brain membranes.
Medical subject headings
- Brain
- Calcium-Binding Proteins
- Gene Expression
- Membrane Glycoproteins
- Nerve Tissue Proteins
- Phylogeny
- Synaptic Vesicles