Appearance of resistance to beta-lactam antibiotics during therapy for Streptococcus pneumoniae meningitis.
case_report · Level V
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- Record sourced from PubMed, PMID 7608819.
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Abstract
A young boy had meningitis caused by Streptococcus pneumoniae that was relatively resistant to penicillin and susceptible to cefotaxime. After 10 days of therapy with penicillin and cefotaxime, fever recurred and a second lumbar puncture revealed a pneumococcus that was resistant to all beta-lactam antibiotics. We now add vancomycin to empiric third-generation cephalosporin therapy for meningitis in children when gram-positive cocci are seen on the cerebrospinal fluid smear.
Medical subject headings
- Meningitis, Pneumococcal
- Streptococcus pneumoniae
- beta-Lactam Resistance