The effects of thiopentone and propofol on delayed hypersensitivity reactions.
rct · Level II
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Abstract
The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg-1 and propofol 2.5 mg kg-1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)-induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.
Medical subject headings
- Dermatitis, Allergic Contact
- Immune Tolerance
- Propofol
- T-Lymphocytes
- Thiopental