Cloning and expression of two brain-specific inwardly rectifying potassium channels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7624316.
- Also identified by PMC identifier 41407.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have cloned two inwardly rectifying K+ channels that occur selectively in neurons in the brain and are designated BIRK (brain inwardly rectifying K+) channels. BIRK1 mRNA is extremely abundant and is enriched in specific brainstem nuclei, BIRK1 displays a consensus phosphate-binding loop, and expression in Xenopus oocytes has shown that its conductance is inhibited by ATP and adenosine 5'-[gamma-thio]triphosphate. BIRK2 is far less abundant and is selectively localized in telencephalic neurons. BIRK2 has a consensus sequence for cAMP-dependent phosphorylation.
Medical subject headings
- Brain Stem
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Telencephalon