Further evidence of a dose-response threshold for haloperidol in psychosis.

Abstract

The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response. During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol. No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected. Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.