Identification of MAGE-1 and MAGE-4 proteins in spermatogonia and primary spermatocytes of testis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7627949.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The MAGE genes encoding tumor rejection antigens recognized by CTLs are expressed at the mRNA level in various cancers and in the testis but not in the other normal tissues. The expression of MAGE-1 or MAGE-4 protein in the testicular cells was studied immunohistochemically with the antibodies to the recombinant MAGE-1 or MAGE-4 protein. Both proteins were identified in the nucleus and cytoplasm of spermatogonia and in primary spermatocytes but not in spermatids or Sertoli's cells. Therefore, MAGE proteins are normal tissue antigens compartmentalized in particular testicular cells playing an important role in the early phase of the spermatogenesis.
Medical subject headings
- Antigens, Neoplasm
- Neoplasm Proteins
- Spermatocytes
- Spermatogenesis
- Spermatogonia