Involvement of the 4q21 region in human malignant melanomas: cytogenetic and immunocytochemical characterization of three primary cell cultures.
basic_science · Level V
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Abstract
The GRO1 oncogene (melanoma growth-stimulating activity alpha) has been localized in region 4q21. The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could have an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different patients, each of which showed clonal chromosomal aberrations involving the 4q21 region.
Medical subject headings
- Chemokines, CXC
- Chromosome Aberrations
- Chromosomes, Human, Pair 4
- Intercellular Signaling Peptides and Proteins
- Melanoma
- Skin Neoplasms