Systemic adenosine infusion: a new treatment modality to alleviate neuropathic pain.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 7644239.
- Also identified by DOI 10.1016/0304-3959(94)00187-J.
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Abstract
Adenosine, an endogenous antinociceptive compound acting in the central nervous system, was infused intravenously (50-70 micrograms/kg/min) to 2 patients with peripheral neuropathic pain. In 1 subject, spontaneous pain was alleviated, and tactile allodynia was essentially relieved during 40 min of infusion. Allodynia to warmth and touch were abolished in the other subject. In addition, hyperalgesia to pinprick was markedly attenuated as was pressure-induced allodynia. The reported effects lasted for hours after termination of the infusion. Our preliminary encouraging data call for further controlled studies of the potentially relieving effect of adenosine in painful neuropathic conditions.
Medical subject headings
- Adenosine
- Neuralgia