X region deletion variants of hepatitis B virus in surface antigen-negative infections and non-A, non-B hepatitis.
case_control · Level III
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Abstract
The etiology of non-A, non-B hepatitis (NANBH) in renal dialysis patients was determined. Hepatitis C virus was present in many, but its appearance did not correlate with elevated alanine aminotransaminase. When sera from these patients were tested for antibodies against hepatitis B virus (HBV) X antigen and polymerase, 70% were positive. HBV infection was confirmed by polymerase chain reaction using several HBV-specific primer pairs. However, amplification with X region primers failed to yield products in many patients. Cloning and sequencing of these products demonstrated deletions within the X region. Hence, X-deletion variants of HBV are strongly associated with NANBH in renal dialysis patients.
Medical subject headings
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Hepatitis C
- Sequence Deletion
- Trans-Activators