Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis.
rct · Level II
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Abstract
Concentrations of carotenoids are low in patients with cystic fibrosis (CF) and are associated with essential fatty acid deficiency and increased markers of inflammation. We conducted single- and multiple-dose studies of beta-carotene supplementation in patients with CF. Dose-proportional increases in beta-carotene concentrations were found, although clearance was independent of dose. Large doses of beta-carotene were necessary to achieve normal plasma levels.
Medical subject headings
- Adjuvants, Immunologic
- Carotenoids
- Cystic Fibrosis