Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion.

O'Callaghan, A; O'Brien, S G; Ninkovic, M; Butcher, G P; Foster, C S; Walters, J R; Roberts, I A · Gut · 1995

case_report · Level V

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Abstract

A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.

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