Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7680431.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A complementary DNA encoding an ATP-regulated potassium channel has been isolated by expression cloning from rat kidney. The predicted 45K protein, which features two potential membrane-spanning helices and a proposed ATP-binding domain, represents a major departure from the basic structural design characteristic of voltage-gated and second messenger-gated ion channels. But the presence of an H5 region, which is likely to form the ion conduction pathway, indicates that the protein may share a common origin with voltage-gated potassium channel proteins.
Medical subject headings
- Adenosine Triphosphate
- Barium Compounds
- Chlorides
- Kidney Medulla
- Potassium Channels