Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 7681997.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval. The second course was identical to the first one or delivered 25 Gy/10 fractions/14 days. No difference in overall survival, nor in the neurologic response or in the incidence of complications was demonstrated. Two clinical factors appeared to be prognostic of the overall survival: the presence of multiple brain metastases and the presence of extracerebral metastases.
Medical subject headings
- Brain Neoplasms
- Cranial Irradiation
- Palliative Care