The "trap" hypothesis of venous ulceration.
basic_science · Level V
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- Record sourced from PubMed, PMID 7682272.
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Abstract
The pathogenesis of venous ulceration is unknown. We propose that macromolecules leaking into the dermis as a result of venous hypertension bind to or "trap" growth factors and matrix material, which then become unavailable for tissue repair and for the maintenance of tissue integrity.
Medical subject headings
- Fibrin
- Fibrinogen
- Growth Substances
- Varicose Ulcer
- alpha-Macroglobulins