Expression of simian virus 40 large T (tumor) oncogene in mouse chondrocytes induces cell proliferation without loss of the differentiated phenotype.
basic_science · Level V
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- Record sourced from PubMed, PMID 7682698.
- Also identified by PMC identifier 46285.
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Abstract
We have infected primary embryonic mouse limb chondrocytes with a retrovirus carrying simian virus 40 early regions and have obtained a monoclonal mouse chondrocyte line, MC615, that was able to grow on culture dishes for at least 7 months and 20 passages. MC615 cells show expression of simian virus 40 large T (tumor) antigen and express markers characteristic of cartilage in vivo, such as types II, IX, and XI collagen, as well as cartilage aggrecan and link protein. These data show that cell growth induced by large T oncogene expression does not prevent the maintenance of the chondrocytic phenotype.
Medical subject headings
- Antigens, Polyomavirus Transforming
- Cartilage
- Cell Division
- Cell Transformation, Viral
- Oncogenes