Calcium agonists and antagonists of the dihydropyridine type: effect on nicotine-induced antinociception and hypomotility.
basic_science · Level V
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Abstract
The influence of a calcium agonist (BAYK 8644) and several calcium channel blockers on nicotine-induced antinociception was investigated in mice. The effect of nicotine was sharply increased by BAYK 8644. This potentiation by BAYK 8644 was blocked by pretreating the animals with nifedipine at 2 and 10 mg/kg. The calcium channel antagonists, nifedipine and nimodipine at doses that had no effect on tail-flick time, reduced significantly the antinociception induced by nicotine (1.5 mg/kg, s.c.). However, the effect of verapamil on nicotine was not significant. These results indicate that DHP calcium channels (type L-channel) play a role in some of the pharmacological effects of nicotine, particularly, locomotor activity and antinociception.
Medical subject headings
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
- Calcium Channel Blockers
- Motor Activity
- Nicotine
- Nociceptors
- Receptors, Cholinergic