Opioid hyperexcitability: the application of alternate opioid therapy.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 7688888.
- Also identified by DOI 10.1016/0304-3959(93)90232-E.
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Abstract
Three cases are reported where patients experienced severe central nervous system adverse effects on high-dose hydromorphone. These effects were rapidly alleviated following a change in therapy to morphine at 20-25% of the usually accepted potency equivalent dose. We recommend caution in using equivalent dose tables when changing opioid therapy in patients receiving high-dose opioid treatment.
Medical subject headings
- Narcotics
- Pain