Role of renin-angiotensin system in blood pressure regulation in pregnancy.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 7707813.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We gave captopril (25 mg) to nine pregnant and eight non-pregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15.0 [SE 2.5] vs 5.2 [1.2] mm Hg; difference 9.8 [95% CI 3.9-15.9] mm Hg, p = 0.0036), whereas plasma renin activity increased significantly more in the pregnant group (18.0 [5.5] vs 4.5 [1.9] ng mL-1 h-1; difference 13.5 [0.71-26.5], p = 0.043). These findings support the hypothesis that stimulation of the renin-angiotensin system in pregnancy maintains blood pressure.