Neuromuscular disease: rehabilitation and electrodiagnosis. 1. Anatomy and physiology of nerve and muscle.

Abstract

This article of the Self-Directed Physiatric Education Program to assist practitioners and trainees in physical medicine and rehabilitation identifies the anatomy and physiology of nerve, neuromuscular junction, and muscle as they relate to rehabilitation of diseases affecting these structures. Structural relationships of the spinal roots, peripheral nerves, motor units, and muscle fibers are outlined, with structural, functional, and electrodiagnostic correlations. Features of nerve and muscle biochemistry and physiology are reviewed as they relate to common neurological diseases, age, and sex. The spontaneous potentials, motor unit activities, and nerve conduction abnormalities found in diseases of nerve and muscle also are described.