Humoral and cell-mediated immune responses in healthy children after one or two doses of varicella vaccine.
rct · Level II
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- Record sourced from PubMed, PMID 7742436.
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Abstract
This study compared the immune responses of healthy children to one or two doses of Oka/Merck varicella vaccine. Both cell-mediated and humoral immune responses were significantly stronger 1 year later among children given two doses 3 months apart than among those given a single dose. Long-term follow-up studies are needed to determine whether two doses of vaccine indeed provide more complete and more durable protection than a single dose against breakthrough varicella in healthy children.
Medical subject headings
- Antibodies, Viral
- Chickenpox
- Herpesvirus 3, Human
- Vaccines, Attenuated
- Viral Vaccines