Pattern of neurobehavioral deficits associated with interferon alfa therapy for leukemia.
case_control · Level III
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Abstract
We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.
Medical subject headings
- Behavior
- Cognition
- Interferon-alpha
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive