Permanent heterotopic ossification at the injection site after diphtheria-tetanus-pertussis immunizations in children who have fibrodysplasia ossificans progressiva.
case_control · Level III
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Abstract
In patients who have fibrodysplasia ossificans progressiva, routine childhood diphtheria-tetanus-pertussis immunizations administered by intramuscular injection caused a significant risk of permanent heterotopic ossification at the site of injection (p < 10(-8)), whereas measles-mumps-rubella immunizations administered by subcutaneous injection posed no significant risk. Intramuscular injections should be avoided, if possible, once a diagnosis of fibrodysplasia ossificans progressiva has been established.
Medical subject headings
- Diphtheria-Tetanus-Pertussis Vaccine
- Measles Vaccine
- Mumps Vaccine
- Myositis Ossificans
- Ossification, Heterotopic
- Rubella Vaccine