Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7753860.
- Also identified by PMC identifier 42004.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We have attempted to model human metastatic disease by implanting human target organs into the immunodeficient C.B-17 scid/scid (severe combined immunodeficiency; SCID) mouse, creating SCID-hu mice. Preferential metastasis to implants of human fetal lung and human fetal bone marrow occurred after i.v. injection of human small cell lung cancer (SCLC) cells into SCID-hu mice; the homologous mouse organs were spared. Clinically more aggressive variant SCLC cells metastasized more efficiently to human fetal lung implants than did cells from classic SCLC. Metastasis of variant SCLC to human fetal bone marrow was enhanced in SCID-hu mice exposed to gamma-irradiation or to interleukin 1 alpha. These data indicate that the SCID-hu mice may provide a model in which to study species- and tissue-specific steps of the human metastatic process.
Medical subject headings
- Bone Marrow Transplantation
- Carcinoma, Small Cell
- Lung Neoplasms
- Lung Transplantation
- Neoplasm Metastasis
- Transplantation, Heterologous