Complete reconstitution of mouse liver with xenogeneic hepatocytes.
basic_science · Level V
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- Record sourced from PubMed, PMID 7761429.
- Also identified by PMC identifier 41823.
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Abstract
We have developed a system for studying hepatocellular growth potential in which liver cells are introduced into the diseased livers of albumin-urokinase (Alb-uPA) transgenic mice. To use this system to study xenogeneic cell transplantation, rat liver cells were introduced into immunotolerant Alb-uPA transgenic mice. In regenerated recipient livers, up to 100% of hepatocellular gene expression was of rat origin, demonstrating the creation of a functional mouse liver in which parenchyma is derived from xenogeneic (rat) hepatocytes. Immunotolerant Alb-uPA transgenic mice provide a tool for studying hepatocellular biology of any species, including humans, in a controlled experimental setting.
Medical subject headings
- Cell Transplantation
- Liver
- Liver Regeneration
- Transplantation, Heterologous