Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
basic_science · Level V
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- Record sourced from PubMed, PMID 7777524.
- Also identified by PMC identifier 41707.
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Abstract
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
Medical subject headings
- Drug Design
- Peptides