Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.
basic_science · Level V
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- Record sourced from PubMed, PMID 7777531.
- Also identified by PMC identifier 41714.
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Abstract
Infection by human immunodeficiency virus type 1 (HIV-1) causes acquired immunodeficiency syndrome (AIDS) after a long clinical latency. This disease is associated with a spectrum of cancers. Here we report that wild-type p53 is a potent suppressor of Tat, a major transactivator of HIV-1. Reciprocally, Tat inhibits the transcription of p53. Downregulation of p53 by upregulated tat may be important for the establishment of productive viral infection in a cell and also may be involved in the development of AIDS-related malignancies.
Medical subject headings
- Gene Products, tat
- HIV-1
- Tumor Suppressor Protein p53