Lack of effect of clonidine on stuttering in children.

Abstract

The authors studied the effects of the alpha 2-receptor agonist clonidine on stuttering in children. Using a double-blind crossover study, they gave placebo or 4 micrograms/kg body weight per day to 25 stuttering children who were 6-13 years old. Stuttering was measured by counting the occurrences of four elementary speech difficulties and by asking parents and teachers to give an overall impression of the amount of stuttering, as well as their impression of how troublesome the stuttering was to the children. Clonidine did not improve stuttering. Clonidine cannot be recommended as a useful drug for treating children who stutter.