Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease.
case_report · Level V
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Abstract
A 45-year-old woman with pulmonary hypertension and mixed connective tissue disease (MCTD) underwent right heart catheterization to evaluate the effects of vasodilators. Nasal oxygen at 2 l/min in addition to 300 mg diltiazem improved pulmonary hemodynamics without adverse effects. After 1 year of diltiazem and home oxygen, sustained favorable hemodynamic effects were obtained, which were more marked than the acute effects. We conclude that this combination may be a potent treatment for pulmonary hypertension in patients with MCTD.
Medical subject headings
- Diltiazem
- Hypertension, Pulmonary
- Mixed Connective Tissue Disease
- Oxygen Inhalation Therapy