Successful therapy for cerebral phaeohyphomycosis due to Dactylaria gallopava in a liver transplant recipient.
case_report · Level V
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Abstract
A 68-year-old liver transplant recipient who was being treated with FK 506 and immunosuppressive steroid therapy was admitted to our medical center because of a tonic-clonic seizure. Computed tomography of the head revealed multiple discrete cerebral abscesses, and culture of fluid drained intraoperatively yielded a dematiaceous fungus. The isolate was susceptible to amphotericin B and itraconazole but was resistant to flucytosine and fluconazole. The patient was successfully treated with a prolonged course of amphotericin B colloidal dispersion and itraconazole, as evidenced by both clinical and radiographic resolution of disease over a 2-year follow-up.
Medical subject headings
- Brain Abscess
- Liver Transplantation
- Mitosporic Fungi
- Mycoses