The novel activation of ABL by fusion to an ets-related gene, TEL.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7805037.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In human leukemia, activation of the ABL proto-oncogene locus on chromosome 9 most commonly occurs as a result of its fusion to the BCR locus on chromosome 22. The resulting chimeric protein displays an elevated tyrosine kinase activity. We have identified a novel activation of ABL which involves a gene located on chromosome 12, designated TEL. Like BCR, TEL is fused in-frame with ABL and produces a fusion protein with an elevated tyrosine kinase activity when assayed in an immune complex. The amino-terminal sequences of TEL encode a helix-loop-helix motif which may mediate dimerization.
Medical subject headings
- Chromosomes, Human, Pair 12
- Cloning, Molecular
- Gene Expression Regulation, Neoplastic
- Genes, abl
- Transcription Factors