Healing of rickets during vitamin D therapy despite defective vitamin D receptors in two siblings with vitamin D-dependent rickets type II.
case_report · Level V
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- Record sourced from PubMed, PMID 7815207.
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Abstract
We report the healing of severe rickets despite hypocalcemia in two siblings with absent vitamin D receptors; long periods of treatment with excessive doses of vitamin D led to relative hypoparathyroidism and a return to normal of calcium metabolism during calcitriol treatment. This finding suggests that some other regulating factor may substitute for the defective vitamin D receptor.
Medical subject headings
- Hypophosphatemia, Familial
- Receptors, Calcitriol
- Vitamin D