Ureteral amyloid deposits of beta 2-microglobulin origin in both kidney recipients of 1 donor.

Abstract

We report on 2 renal transplant recipients with ureteral amyloid deposits, each of whom received 1 kidney from the same donor. Ureteral stenosis developed in both cases. Immunohistochemistry revealed beta 2-microglobulin derived AB amyloid within the stenotic parts of the ureters, which to our knowledge has not been described previously at that site. Usually AB amyloid is found in patients on long-term hemodialysis. Amyloid transfer by transplantation as a possible cause for ureteral stenosis was excluded because the donor had had normal renal function and autopsy showed no evidence of amyloidosis. It is more likely that the secondary deposit of AB amyloid in the transplanted ureters was facilitated by preexisting ischemic ureteral damage.