Mucocutaneous reactions to gold: a prospective study of 74 patients with rheumatoid arthritis.
prospective_cohort · Level II
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Abstract
To describe causality, morphology, course, and risk factors of mucocutaneous reactions to gold. A prospective study of 74 patients with rheumatoid arthritis starting with gold thioglucose. Thirty-nine patients experienced an episode of gold dermatitis. Sixteen patients continued gold treatment. The estimated treatment withdrawal at 1 year was 26%. The clinical picture was variable and nonspecific. Gold dermatitis was associated with HLA-B35 and disease duration. Mucocutaneous reactions to gold are nonspecific, therefore a causality assessment is necessary. Incidence is high, but treatment can often be continued with dose reduction and local steroids. The predictive value of risk factors is low.
Medical subject headings
- Arthritis, Rheumatoid
- Aurothioglucose
- Drug Eruptions