Loss of detectable antibody to hepatitis B surface antigen in immunized patients with hemophilia but without human immunodeficiency virus infection.
retrospective_cohort · Level III
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Abstract
We investigated the loss of detectable antibody directed against the hepatitis B surface antigen after immunization with hepatitis B vaccine in 55 patients who were seronegative for the human immunodeficiency virus and had hemophilia. Twenty percent of patients lost detectable antibody at a mean of 4.6 years after completion of immunization. Monitoring of hepatitis B serostatus or routine revaccination may be necessary.
Medical subject headings
- HIV Seronegativity
- HIV-1
- Hemophilia A
- Hepatitis B Antibodies
- Hepatitis B Surface Antigens
- Hepatitis B Vaccines