Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy.

Garcia, P A; Laxer, K D; van der Grond, J; Hugg, J W; Matson, G B; Weiner, M W · Ann Neurol · 1995

case_series · Level IV

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Abstract

Proton magnetic resonance spectroscopic imaging (1H MRSI) has demonstrated decreased N-acetyl compounds (NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.

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