Inhibition of Shiga-like toxins by brefeldin A.
basic_science · Level V
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- Record sourced from PubMed, PMID 7876627.
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Abstract
The effects of Shiga-like toxins on the morphology and protein synthetic capability of HeLa cells in tissue culture could be prevented by brefeldin A, an inhibitor of certain intracellular Golgi functions. Brefeldin A was without effect on the binding of Shiga-like toxin to cells. These results provide evidence that the Shiga-like toxins are first processed by the Golgi before moving to their 60S ribosome target site.
Medical subject headings
- Anti-Bacterial Agents
- Bacterial Toxins
- Cyclopentanes
- Enterotoxins