p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus.
basic_science · Level V
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- Record sourced from PubMed, PMID 7877979.
- Also identified by PMC identifier 42515.
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Abstract
Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the induction of a G1/S arrest or apoptosis as a response to DNA damage. Transforming proteins of several oncogenic DNA viruses inactivate tumor suppressor activity of p53 by blocking this cellular response. To test whether hepatitis B virus displays a similar effect, we studied the p53-mediated cellular response to DNA damage in 2215 hepatoma cells with replicative hepatitis B virus. We demonstrate that hepatitis B virus replication does not interfere with known cellular functions of p53 protein.
Medical subject headings
- DNA Damage
- Hepatitis B
- Tumor Suppressor Protein p53