A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 7878036.
- Also identified by PMC identifier 42580.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridize to avirulent members of the same species. The EPEC locus and a different virulence locus of uropathogenic E. coli insert into the E. coli chromosome at the identical site and share highly similar sequences near the point of insertion.
Medical subject headings
- DNA, Bacterial
- Enteritis
- Escherichia coli
- Genes, Bacterial