Suckling-induced changes in responsivity to the hypoalgesic effect of morphine.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 7892018.
- Also identified by DOI 10.1016/0304-3959(94)90073-6.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The hypoalgesic effect of morphine in lactating rats was assessed using the hot-plate test. At midlactation (days 12 and 18 postpartum) females nursing litters of 8 pups were less responsive to the hypoalgesic effect of morphine than ovariectomised or cycling females and females on days 6 or 24 of lactation. Subsequent studies showed that the hypoalgesic response to morphine was inhibited in lactating rats at a number of time points after drug administration and across a variety of doses. This effect was not dependent on milk delivery but was dependent on the hormonal state of the female since separation of dams and their litters for 96 h was sufficient to reinstate the response to morphine if it resulted in a reappearance of vaginal estrus.
Medical subject headings
- Analgesics
- Lactation
- Maternal Behavior
- Morphine