Which plasma factors bring about disturbance of endothelial function in pre-eclampsia?

Arbogast, B W; Leeper, S C; Merrick, R D; Olive, K E; Taylor, R N · Lancet · 1994

review · Level V

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Abstract

The characteristic pathophysiological changes in pre-eclampsia are thought to be related to abnormalities of the maternal vascular endothelium. We suggest that the blood components that affect the risk of such damage are very-low-density lipoproteins (VLDL), which injure the endothelium, and toxicity-preventing activity (the pl 5.6 form of plasma albumin), which protects against VLDL-induced injury.

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