Influence of carbamazepine on the dose-response relationship of vecuronium.
case_control · Level III
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Abstract
We have determined the cumulative dose-response relationship for vecuronium from the evoked compound electromyogram of the hypothenar muscles in eight patients who were receiving carbamazepine. The ED50, ED90 and ED95 were 29, 52 and 64 micrograms kg-1, respectively, and were significantly different (P < 0.05) from those of a control group (ED50, ED90 and ED95 21, 36 and 44 micrograms kg-1, respectively).
Medical subject headings
- Carbamazepine
- Vecuronium Bromide